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Monkeypox Virus
 
June 16, 2003
Arizona Game and Fish Department Wildlife Health Advisory
Issued
 
Agency Directive:
Order related to trade of African rodents to preclude spread of Monkeypox
 
Background
Monkeypox is a rare viral disease that is found mostly in the rainforest countries of central and west Africa. The disease is called "monkeypox" because it was first discovered in laboratory monkeys in 1958. Blood tests of animals in Africa later found evidence of monkeypox infection in various rodent species. In early June 2003, monkeypox was reported among several residents in the United States who became ill after having contact with sick pet prairie dogs that originated in a pet store in Chicago. This is the first evidence of community-acquired monkeypox in the United States.

As of June 14, a total of 81 persons with suspected monkeypox had been reported in Wisconsin (34), Illinois (19), Indiana (26), and Ohio (2). Monkeypox had been confirmed by laboratory tests in nine persons. At least 14 of the people with suspected monkeypox had been hospitalized for their illness; there have been no deaths related to the outbreak. There is one potential case in a person in Arizona who was bitten by a prairie dog in Texas; test results are pending.
 
Directive from The Center for Disease Control and The Food and Drug Administration
On June 11, 2003, CDC and FDA issued a joint order announcing an immediate embargo on the importation of all rodents from Africa due to the potential that these rodents can spread monkeypox virus infection to other animals and to humans. The joint order also banned within the United States any sale, offering for distribution, transport, or release into the wild, of prairie dogs and six specific African rodent species implicated in the current monkeypox outbreak. The six species from Africa are: Tree squirrels (Heliosciurus sp.), Rope squirrels (Funisciurus sp.), Dormice (Graphiurus sp.), Gambian Giant Pouched Rats (Cricetomys sp.), Brush-tailed porcupines (Atherurus sp.), and Striped mice (Hybomys sp.). The joint order applies to animals that are living or dead. Individuals may only transport prairie dogs and the six specified rodents from Africa to veterinarians or animal control officials.
 
Clinical Sign in Humans

In humans, monkeypox is similar to smallpox, although it is often milder. Unlike smallpox, monkeypox causes lymph nodes to swell. The incubation period for monkeypox is about 12 days (range 7 to 17 days). The illness begins with fever, headache, muscle aches, backache, swollen lymph nodes, a general feeling of discomfort, and exhaustion. Within 1 to 3 days (sometimes longer) after the appearance of fever, the patient develops a papular rash (i.e., raised bumps), often first on the face but sometimes initially on other parts of the body. The lesions usually develop through several stages before crusting and falling off.

 
Arizona Game and Fish Action
All personnel need to be aware of this order and if any African rodents, particularly those listed in this advisory, are observed in pet stores you need to contact: Elisabeth Lawaczeck, DVM State Public Health Veterinarian Office of Infectious Diseases Services Arizona Department of Health Services 602-230-5820
 
For more information
More information on the current monkeypox outbreak in the Midwest can be obtained at: http://www.cdc.gov/ncidod/monkeypox/index.htm
 
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